Folic acid supplementation for stroke prevention in patients with cardiovascular disease This study examined the effect of folic acid supplementation on stroke prevention in patients with cardiovascular disease (1). Multiple medical databases were searched to identify appropriate studies. Relative risks were used to examine the association. Statistical analyses were conducted. The results showed that 11 studies with 65,790 patients were included. Folic acid supplementation was associated with a significant benefit in reducing risk of stroke in patients with cardiovascular disease. Greater effects were seen in participants with decreased homocysteine concentrations, those with doses of less than 2mg, and populations in regions with no or partly fortified grain. The authors conclude that folic acid supplementation is effective in stroke prevention in these populations.