In this randomized, controlled, double-blind trial, the researchers compared the effect of calcium supplementation with vitamin D on non-alcoholic fatty liver disease regression during a hypo-energetic program (1). The experiment lasted 12 weeks using 120 patients receiving 25 mcg of calcitriol and 500mg of calcium carbonate, or placebo. The results showed that weight, BMI, and fat mass reduction were significant in each group after 12 weeks of intervention, but the differences among groups was not significant. The calcium plus calcitriol group showed a significant decrease in ALT and FPG and increase in HDL.C level compared with the calcitriol group, adjusted to the baseline measures (p < 0.001). The authors conclude that calcium plus calcitriol supplementation for 12 weeks may be potentially effective for biochemical parameters in NAFLD patients.