This systematic review and meta-analysis examined the effects of probiotic supplementation in children for functional constipation ⁽¹⁾. They included 4 trials reporting data on 382 children with functional constipation. Overall, there were no significant differences in treatment success, spontaneous bowel movements per week, fecal soiling episodes per week, straining at defecation, use of lactulose, use of laxatives, fecal incontinence, pain during defecation, flatulence, and adverse events between probiotics and placebo. Further, the use of probiotics was associated with lower frequency of glycerin enema use and abdominal pain. The authors conclude that the use of probiotics was associated with significant improvement in glycerin enema use and abdominal pain but did not affect the treatment success and other function indices.