This meta-analysis investigated 9 randomized trials with regards to whole grain consumption and the concentration of inflammatory markers (1). The results showed that totally 9 randomized trials included 838 participants were identified. In a pooled analysis of all studies, consumption of whole grains had an inverse association with inflammatory markers, including C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β). Specific analyses for CRP and IL-6 yielded that whole grain diet was related with a significant decrease in the concentration of CRP and IL-6. The authors conclude that citizens could benefit from increased whole grain intake for reducing systemic inflammation.