In this study, the authors detailed a summary of the evidence on natural treatments for depression (1). A systematic review and meta-analysis was conducted. Positive results were seen including studies of SAMe, methylfolate, omega-3, vitamin D. Supportive studies were found for creatine and amino acid combinations. Mixed results were found for zinc, folic acid, vitamin C. Non-significant studies were found for a few items as well. The authors conclude that clinical considerations are required when psychiatrists are considering prescribing nutrients, including the knowledge of drug interactions.