This study was conducted to evaluate different doses of Vitamin D on the metabolic profiles of those with polycystic ovary syndrome (PCOS) (1). It was randomized, double-blind, placebo-controlled in 90 patients. Patients received 4000IU or 1000IU per day for 12 weeks. Results showed the higher dose led to reduced fasting plasma glucose, serum insulin, triglycerides, other cholesterol measures. The authors conclude that overall, vitamin D supplementation at a dosage of 4 000 IU/day for 12 weeks in insulin-resistant patients with PCOS had beneficial effects of glucose metabolism and lipid profiles compared with 1 000 IU/day of vitaminD and placebo groups.