The following review discusses an experimental strategy for the co-administration of quercetin and vitamin C for the prophylaxis and treatment of SARS-CoV-2 related illness (1). The current evidence is that vitamin C and quercetin act synergistically by exerting antiviral properties by interfering with factors associated with viral pathogenicity (i.e. entry, replication, assembly and enzymatic activity), and displaying immunomodulatory effects via stimulating interferon production, T-cell and phagocytic activity. The antiviral and immune responses are enhanced by vitamin C’s ability to recycle oxidized quercetin thus reinforcing its therapeutic effects. The authors proposed optimal dosing recommendations specific to the population needs: prophylaxis and mild cases (quercetin 250-500mg BID and vitamin C 500mg BID), and severe cases (quercetin 500mg BID and vitamin C 3gr q6 for 7 days). In conclusion, co-administration of the two safe and inexpensive nutraceuticals is suggested for integrative use in high-risk populations for the prevention and treatment of SARS-CoV-2.