Premenstrual Syndrome (PMS) is a condition affecting physical, psychological, and behavioral well-being of 80-90% of women in their reproductive years during menstrual cycles. The following study evaluates the efficacy of Iranian Borage, Echium amoenum (EA), in the treatment of PMS for female college students ages 18-35 years old with 28-35 day cycles1. The EA group received 450 mg capsules (150mg of EA standardized extract TID) from day 21 to day 3 of their next menstrual cycle for a period of two consecutive cycles relative to an inert placebo. The severity of PMS was measured using the premenstrual symptoms screening tool (PSST). Statistically significant differences were seen in the EA group (p ≤ 0.001) in the average scores from 35.3 to 16.1 at baseline to 2 months, respectively, compared to placebo (p = 0.09) from 31.0 to 28.3. EA had the greatest impact on providing symptomatic relief for anxiety, tension and tearfulness.