In a randomized, double-blind controlled trial (1), 60 adults with mild to moderate knee osteoarthritis were administered twice per day after meals capsules of an herbal formulation of turmeric, ginger, and black pepper extracts containing respectively 300 mg of curcumin, 7.5 mg of gingerols, and 3.75 mg of piperine, or a 250 mg capsule of Naproxen twice in the morning and night for 4 weeks. There were no significant differences in the distribution of demographic characteristics nor in food intake. Blood samples were collected before and after the intervention to assess the inflammatory biomarker prostaglandin E2 (PGE2). The results showed that both groups had a significant decrease of 27 pg/mL in PGE2 (p <.001). However, the differences between the Naproxen and herbal formulation groups were not significant (pre: p = .363, post: p = .112, intervention). Overall, the synergistic effect of the three botanicals mediated inflammation similarly to Naproxen and the authors suggest it could be used as a safer alternative to NSAIDs.