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Anthocyanins’ Effect on Systemic and Vascular Inflammation

Anthocyanins are bioflavonoids with antioxidant activity. A meta-analysis aimed to determine the effects of anthocyanins on markers of systemic and vascular inflammation in adults > 18 years old.[1] It included 32 randomized, controlled trials from five electronic databases. It found that intake of anthocyanins significantly decreased levels of C‑reactive protein (CRP; p = 0.003), interleukin‑6 (IL‑6; p = 0.004), tumor necrosis factor‑alpha (TNF‑α; p = 0.023), intercellular adhesion molecule‑1 (p = 0.002), and vascular adhesion molecule‑1 (VCAM‑1; p < 0.001). Adiponectin levels were found to significantly increase (p = 0.004). Levels of interleukin‑1beta (IL‑1β; p = 0.793) and P‑selectin (p = 0.219) did not increase. Further, the authors determined, through subgroup analysis, that higher doses of anthocyanins were associated with a more significant decrease in CRP, IL‑6, TNF‑α, and VCAM‑1. Overall, the authors concluded that anthocyanins significantly decrease levels of markers for systemic and vascular inflammation.