A study published in December 2020 out of Sweden and Norway looked at the impact of supplementing Selenium and CoQ10 on elderly patients with chronic kidney disease who were deficient in these nutrients. In a randomized double-blind placebo controlled prospective trial consisting of 215 individuals with mean age of 71 years, one group received 200ug/day of selenium yeast and 200mg/day of CoQ10, while the control group received a placebo. Measures of renal function were assessed at the start, at 48 months and after 5 years. Changes in renal function were measured via creatinine, cystatin-C and the Chronic Kidney Disease Epidemiological Collaboration (CKD - EPI) algorithm and eGFR. The intervention group showed significantly lower serum creatinine and cystatin-C concentration compared to the placebo group at both follow-up intervals (p < 0.0001), with more significant improvement in renal function at the five-year follow-up.