In this study, the authors discuss the possible protective role of niacinamide, a derivative of niacin, against skin cancer recurrence.[1] They prospectively evaluated whether total, dietary, and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984–2010) and 41,808 men in the Health Professionals Follow-up Study (1986–2010). The results of their analysis were that higher total niacin intake was also marginally positively associated with melanoma risk in men, but not in women. The results were similar in stratified analyses according to sun exposure–related factors and by body location of melanoma and squamous cell carcinoma.