December 2, 2019
Health Canada Alert: Xeljanz (tofacitinib) risk of thrombosis

An increased incidence rate of thrombosis, including pulmonary embolism, deep vein thrombosis, and arterial thrombosis was observed in patients treated with XELJANZ (tofacitinib) in a large, ongoing post-marketing study. The study showed that patients with rheumatoid arthritis and at least one cardiovascular risk factor should not have their dose doubled given the risk of thrombosis.