In this article, the authors ask which treatments are the best for vitiligo ^[1]. Combination therapies, specifically those using light (narrowband UV-B) are associated with more improved repigmentation than single therapies. There is limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo. However, combination therapies were associated with more adverse effects.