This systematic review examined the body of evidence on the efficacy of coenzyme Q10 supplementation in the treatment of patients with cardiovascular disease (CVD) ⁽¹⁾. All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. The results showed that extracted data for seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies. The authors conclude that the evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.