In this study, the authors evaluated the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients ⁽¹⁾. Fifty subjects with elevated serum thyroid stimulating hormone (TSH) levels (4.5-10 μIU/L) aged between 18 and 50 were randomized in either treatment (n = 25) or placebo (n = 25) groups for an 8-week treatment period. Ashwagandha root extract (600 mg daily) or starch as placebo. Efficacy Variables: Serum TSH, serum triiodothyronine (T3), and thyroxine (T4) levels. Ashwagandha treatment effectively normalized the serum thyroid indices during the 8-week treatment period in a significant manner. The authors conclude it may be helpful for this patient population.