2019-02-11 12:57:37
Vitamin D insufficiency is common in older people and may lead to increased bone resorption, bone loss, and increased falls and fractures. This study examined the effect of Vitamin D supplementation on bone mineral density at the hip. A total of 379 adults aged ≥70 y (48% women; mean age: 75 y) from the northeast of England were randomly allocated to 1 of 3 doses of vitamin D3 [12,000 international units (IU), 24,000 IU, or 48,000 IU] given once a month. The primary outcome was change in BMD (ΔBMD) at the hip. Secondary endpoints comprised the dose effects on femoral neck BMD, falls, circulating calciotropic hormones, bone turnover markers, and adverse events. The authors conclude that there was no difference in change in BMD over 12 mo between the 3 doses of vitamin D, suggesting no effect of the intervention or a similar attenuation of the anticipated decrease in BMD over 12 mo. The treatment was safe and effective in increasing plasma 25(OH)D concentrations, with no dose-related adverse events.
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- Aspray TJ, et al. Randomized controlled trial of vitamin D supplementation in older people to optimize bone health. Am J Clin Nutr. 2019.
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