2019-02-11 12:57:37
Vitamin D (VD) deficiency has been associated with increased incidence and severity of atopic dermatitis (AD), but the mechanisms through which VD may ameliorate AD are unclear. In this study, the authors compared the phenotypic characteristics of circulating myeloid and plasmacytoid dendritic cells of children with AD vs. healthy controls (HC), and evaluated if VD can modulate the allergic phenotype of circulating DCs in AD patients (1). There was no difference in frequency of circulating DCs between groups, among children with AD. The authors conclude that, in summary, VD decreases the allergic phenotype of circulating DCs in children with AD, a potential mechanism for how VD supplementation may improve AD severity.
[collapsed title=”Reference:”]
- Cristi F, et al. Vitamin D modulates the allergic phenotype of dendritic cells in children with atopic dermatitis. Exp Dermatol. 2019.
[/collapsed]